Sample Geometry
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Ideally, the sample should be cylindrical for the best image. X-rays will be attenuated similarly at every angle (except for highly non-homogenous materials) allowing for easier reconstructions. Cylindrical samples also make it easier for the operator to center the sample on the detector which can effectively increase the spatial resolution of the image due to a smaller field of view.
If a cylindrical geometry is not possible, the sample should be tilted so that as few straight edges are perpendicular to the x-ray beam as possible. X-ray scattering artifacts are especially enhanced at straight edges, causing streaking artifacts that propagate from the edges. Also, greater care should be taken to center the sample on the detector.